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Milestones

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2007

  • Capsulin™ oral insulin receives world-wide media attention and positive comments from diabetes charities
  • Positive results from Capsulin™ oral insulin phase II in type 2 diabetes presented at 67th Scientific Sessions of the ADA
  • Capsitonin™ oral calcitonin successfully completes recruitment and dosing of 36-patient phase II study
  • Bone Medical Ltd raises A$2.1M with exercise of options
  • Infexion successfully develops a new immunostimulatory presentation system for nasal or parenterally delivered vaccinations
  • Recognition of calcitonin as effective therapeutic for osteoarthritis
  • Arthritis drug candidate that downregulates TNF (BN006) undergoing advanced testing at the Kennedy Institute lead by Professor Feldmann
  • Phase II trial on oral insulin product Capsulin™ in patients with type 2 diabetes positive
  • Ethics approval for phase II Axcess formulated calcitonin (Capsitonin™) study in osteoporosis
  • US freedom-to-operate review completed on Axcess 2 and 3 patent families

2006

  • First repeat dosing of Capsulin™ oral insulin achieved in phase II study on patients with type 2 diabetes
  • Positive results from preclinical study into Axcess formulated oral GLP-1 analogues
  • Bone Medical Ltd raises A$1.8M in private placement
  • Successful pre-clinical study in TNF downregulator (BN006) for treatment of rheumatoid arthritis
  • Axcess 4 patent successfully filed broadening choices for new proteins to be delivered orally
  • Bone Medical Ltd enters collaboration with Synovo on BN006 testing
  • Pre-IND meeting with FDA regarding Axcess formulated insulin (Capsulin™) for diabetes
  • Positive results announced from phase I trial of Axcess formulated oral PTH product Perthoxal™
  • Pre-IND meeting with FDA regarding Axcess formulated sCT (Capsitonin™) for osteoporosis

2005

  • Enters 'Universal Vaccine' collaboration addressing seasonal and pandemic influenza - two year project gains €1.2 M EU grant
  • Completed phase I trial of Axcess formulated oral PTH product (Perthoxal™)
  • BIO-IB Inc. appointed as financial advisors to Bone Medical Ltd
  • Appointment of Dr Juergen Parrisius as key executive of Proxima Laboratory and Research Services Ltd
  • Capsulin™ results received well at 65th Scientific Sessions of the ADA
  • Positive result in arthritis drug candidate that downregulates TNF (BN006)
  • Positive collagen tolerance study using RIA mouse model
  • Phase IIa trial on oral insulin product Capsulin™ in type 1 diabetes positive
  • Appointment of Tim Earle as Group Commercial Director

2004

  • First positive phase I/II result in man for Axcess formulated calcitonin (Capsitonin™)
  • Appointment of Dr Anthony Lockett as Medical Director of Group and Diabetology Ltd
  • Capsulin™ phase I results get positive reception at 64th Scientific Sessions of the ADA
  • First Mozaic patent granted
  • Lexcicon discovery
  • Discovery of new class of potential arthritis therapeutics which downregulate TNF
  • Establishment of Proxima Laboratory and Management Services Ltd
  • Commencement of Phase IIa with capsule insulin (Capsulin™)
  • Bone Ltd "reverses" into ASX listed company - now Bone Medical Ltd and raises $4.5m

2003

  • First Vaxcine patent granted
  • First positive phase I result in man for Axcess formulated insulin
  • Kancer Ltd established

2002

  • Diabetology Ltd established
  • Bone Ltd established

2001

  • Second MTA Agreement for development of another Axcess formulated peptide with second Multinational
  • MTA Agreement for development of an Axcess formulated peptide with Multinational
  • Acquired: Vaxcine Patents
  • Established Sino/British Joint Venture near Beijing for pre-clinical testing
  • Achieved funding from the International Healthcare Trust

2000

  • First positive preclinical tests for Axcess
  • Lodged first Axcess patent
  • Appointment of Gurpal Bansal as contract lab manager
  • Acquired: Mozaic patents
  • Proxima Concepts Ltd Established
  • Roger New and Glen Travers form new entity to tackle Major Biopharmaceutical industry challenges